Dysfunctional uterine bleedingDysfunctional uterine bleeding causes

Dysfunctional uterine bleedingDysfunctional uterine bleeding causes

Dysfunctional uterine bleeding is caused by dysfunction of the endocrine axis rather than organic lesions of the reproductive organs, and is characterized by abnormal uterine bleeding with menstrual disorders. Long-term bleeding and severe hemorrhagic shock may occur, even threatening life, but it is also critical to infertility, rather than affecting it.

Common causes

1. Systemic factors

This factor mainly includes adverse mental trauma, stress, malnutrition, endocrine and metabolic disorders such as iron deficiency, anemia, aplastic anemia, blood diseases and bleeding diseases, diabetes, and thyroid and adrenal diseases.

2. Dysfunction

The main causes of this disease include disorders in the rhythm of reproductive hormone release, feedback dysfunction, ovulation and corpus luteum dysfunction.

3. Iatrogenic factors

Normal hypothalamic-pituitary-gonadal axis function is disturbed by steroid contraceptives and intrauterine devices. Some systemic diseases, especially those of the psychiatric nervous system, can affect normal menstrual function through neuroendocrine mechanisms.

4. Uterus and endometrium

These include abnormalities in the structure and function of spiral arterioles and microcirculatory vascular beds, dysfunction of endometrial steroid receptors and lysosomes, abnormalities in local coagulation mechanisms, and dysregulation of prostaglandin secretion.

Predisposing factors

Polycystic ovary syndrome

This is the main cause of functional uterine bleeding in women. This disease is mainly manifested by increased androgen levels in women, which in turn causes problems such as hirsutism, acne and obesity.

Hirsutism is a typical manifestation of increased androgen. In addition to the increase in hair on the limbs, a more characteristic feature of Asians is the presence of hair longer than sweat hair on the areola or under the navel. Even if there is only one hair, it has diagnostic significance.