Methods for inducing ovulation in patients with amenorrhea

For amenorrhea patients who desire fertility and have not lost ovarian function, hormones or analogues can be used to induce ovulation.

Principles of inducing ovulation

1. For patients with pituitary insufficiency, follicle-stimulating hormone extracted from urine of postmenopausal women can be used to promote follicle development and secrete estrogen, and combined with chorionic gonadotropin for treatment, which has a high ovulation success rate;

2. For patients with normal pituitary and ovarian function but hypothalamic insufficiency or disharmony, chlorphenamine can be used to correct the function of the hypothalamic pituitary-ovarian axis and induce ovulation;

3. For amenorrhea caused by insufficient endogenous luteinizing hormone-releasing hormone, the use of pulse micro-luteinizing hormone-releasing hormone injection to induce ovulation has a good effect;

4. For patients with hyperprolactinemia, bromocriptine can inhibit the effect of prolactin, restore the secretion of gonadotropin, and thus induce ovulation.

Drugs to induce ovulation

1. Take ethylphenol orally, 0.25-0.5 mg each time, once a night, for 20 consecutive days. It can be repeated 8-10 days after stopping the medication, for 3 consecutive cycles.

2. Inject progesterone intramuscularly, 20 mg each time, once a day, for 3 consecutive days. Withdrawal bleeding may occur 3 to 7 days after stopping the drug. If the next menstruation does not come when it is due, the injection can be repeated for 1 to 3 cycles.

3. Take ethylphenol orally, 0.25-0.5 mg each time, once a day, for 20 consecutive days. 16 days after stopping the drug, inject progesterone 10-20 mg, once a day, for 5 consecutive days. Vaginal bleeding may occur 3-7 days after stopping the drug. It can be used for 3 consecutive cycles, but attention should be paid to the dosage and time of the medication to avoid menstrual disorders and affect the efficacy.

4. Take nialestradiol orally, 5 mg each time, once a month. After the symptoms improve, the maintenance dose is 1-2 mg each time, 1-2 times a month. However, it should be used with caution in patients with asthma, heart and kidney dysfunction, depression, migraine, diabetes, abnormal liver function, thyroid disease, uterine fibroids, etc.