What causes uterine fibroids? What is the relationship between uterine fibroids and estrogen?

During pregnancy, the woman should be closely monitored to prevent miscarriage or premature birth. If the fibroids are too large, it is estimated that it will be difficult to continue the pregnancy and surgery should be performed as soon as possible. However, before that, it is necessary to understand how serious the uterine fibroids are. So how serious are uterine fibroids? What causes them?

When uterine fibroids grow to the size of a fist, other pelvic organs are compressed and the condition becomes more serious. Surgical resection can relieve symptoms. Large fibroids are more likely to worsen than small fibroids. Clinically, fibroids smaller than 2 cm generally have no obvious symptoms. Many patients go to the hospital to check for fibroids and feel that the fibroids are small and will not cause much harm. As a result, the best treatment time is delayed, but this lays the seeds for disaster.

So what is the cause of uterine fibroids?

The main causes of uterine fibroids are as follows:

1. Genetics of uterine fibroids. It is believed that somatic mutation is the initiating event of fibroid formation, and cytogenetics consistently confirm that uterine fibroids have chromosomal structural abnormalities.

2. Uterine fibroids are a type of tissue proliferation. Currently, there is no consensus on the origin of uterine fibroids. Some people believe that it is caused by the proliferation of immature uterine wall smooth muscle cells, and each uterine fibroid originates from a single cell.

3. Uterine fibroids are estrogen-dependent tumors. Estrogen is the main factor that promotes the growth of fibroids. Fibroids rarely occur before puberty in women. Fibroids grow larger as estrogen levels increase during pregnancy and shrink as estrogen levels decrease after menopause. These phenomena have been confirmed.