Early symptoms of hyperprolactinemia in women

Hyperprolactinemia is a disease that is not familiar to everyone. However, after the disease occurs, the patient's menstruation will change significantly, and fertility will also be affected. It will also affect the patient's vision, causing vision loss and headaches, which is extremely harmful. We should learn more about the symptoms and treat them reasonably. So, what are the early symptoms of hyperprolactinemia in women?

(1) Menstrual disorders: primary amenorrhea accounts for 4%, secondary amenorrhea accounts for 89%, oligomenorrhea accounts for 7%, dysfunctional bleeding and luteal insufficiency account for 23% to 77%.

(2) Galactorrhea The incidence of typical amenorrhea-galactorrhea syndrome in non-tumor hyperprolactinemia is 20.84%, in tumor-type hyperprolactinemia is 70.6%, and in simple galactorrhea is 63% to 83.5%. Galactorrhea is overt or occurs when the breast is squeezed and is watery, serous, or milky. The breasts are usually normal.

(3) The incidence of infertility is 70.7%, which may be primary or secondary infertility and is related to anovulation, luteal insufficiency or luteinized unruptured follicle syndrome (LUFS).

(4) Hypoestrogenemia and hyperandrogenism: Decreased estrogen levels cause hot flashes, palpitations, spontaneous sweating, vaginal dryness, dyspareunia, decreased libido, etc. Increased androgen levels cause moderate obesity, seborrheic dermatitis, acne, and hirsutism.

(5) Changes in vision and visual field: When pituitary tumors involve the optic chiasm, they can cause decreased vision, headaches, dizziness, hemianopsia and blindness, as well as functional impairment of cranial nerves II, III and IV, and fundus edema and exudation.

(6) Acromegaly: seen in PRL-GH adenoma, myxedema seen in combined hypothyroidism, some patients have type 2 diabetes and osteoporosis.