What methods are needed clinically to check cervical warts

When it comes to cervical warts, everyone knows that it is a sexually transmitted disease, but many people do not know what the symptoms of cervical warts are, let alone how to check for cervical warts. The following 5 checks can help patients check whether they have cervical warts.

How to Check for Cervical Warts

1. Acetic acid white test

The principle of this test is the result of protein coagulation and bleaching with acid. The keratin produced by HPV-infected cells is different from that produced by normal uninfected epithelial cells, and only the former can be decolorized by acetic acid. The US CDC points out that the acetic acid whitening test is not a specific test and false positives are common.

2. Histochemical examination

A small amount of lesion tissue is taken to make a smear and stained with specific anti-human papillomavirus antibodies. If there is a viral antigen in the lesion, the antigen and antibody will bind. In the peroxidase antiperoxidase (PAP) method, the nucleus can be stained red. This method is highly specific and rapid, which is helpful for examination.

3. Viral wart antibody test

At present, HPV is difficult to detect using traditional virus culture and serological techniques, and the main experimental examination technology is nucleic acid hybridization. The PCR method developed in recent years has the advantages of specificity, sensitivity, simplicity, and rapidity, opening up a new way for HPV detection.

4. Pathological examination

Pathological examination is a very effective method in the examination of cervical warts. It starts with the symptoms of cervical warts and determines whether it is cervical warts through examination. Pathological examination mainly shows parakeratosis, hypertrophy of the spinous layer, papilloma-like hyperplasia, thickening and extension of the epidermal protrusions, and the degree of hyperplasia may be similar to pseudoepithelioma.

5. Histological examination

The peroxidase antiperoxidase method (PAP) is commonly used to show viral proteins in condylomata, to prove the presence of viral antigens in warts. When HPV protein is positive, a weak red positive reaction may appear in the superficial epithelial cells of cervical condylomata.