How to prevent hydatidiform mole from becoming cancerous

How to prevent hydatidiform mole from becoming cancerous?

After suffering from hydatidiform mole, a small number of patients develop malignant changes, which are called malignant hydatidiform mole or invasive hydatidiform mole. After suffering from hydatidiform mole, close follow-up and regular examinations should be carried out. During malignant changes, in addition to the enlargement of the uterus, the chorionic gonadotropin in the blood increases significantly. This is often difficult to distinguish from early pregnancy. In the past, doctors often recommended that patients use contraception for 2 years, but now B-ultrasound or color Doppler ultrasound can accurately see the embryonic sac of early pregnancy and will not be confused with malignant hydatidiform mole. Therefore, it is not necessary to use contraception for 2 years after suffering from hydatidiform mole. For some people who are in urgent need of having children, contraception can be used for half a year or 1 year.

To prevent hydatidiform mole cancer, you should pay attention to the following points:

1. Preventive chemotherapy: It is mainly to prevent the malignant transformation of hydatidiform mole. Preventive chemotherapy should be performed for patients over 40 years old, those who are difficult to follow up regularly, or those who are clinically estimated to have a high possibility of malignant transformation. Preventive chemotherapy generally uses only one drug for one course of treatment, but the dose is the same as that for the treatment of malignant trophoblastic tumors and cannot be reduced.

2. Regular follow-up: Follow-up after hydatidiform mole is very important, which can detect the tendency of malignant transformation early and provide timely treatment. Generally speaking, after curettage, urine hCG or concentrated urine is checked once a week until it turns negative, and after radioimmunoassay drops to normal values, blood or urine is checked every 2 weeks or 1 month. After three months, check once a month or every 2 months, and after half a year or a year, check once every half a year to a year, for at least three years, or even for more than 10 to 15 years. If the patient has clinical symptoms during the follow-up process, other necessary examinations should be performed at any time. After treatment of hydatidiform mole, contraception should be used for at least 1 to 2 years to avoid difficulty in distinguishing between re-pregnancy and malignant transformation.

Experts remind: Most hydatidiform mole is a benign lesion. As long as vacuum suction and uterine contraction agents can remove foreign objects in the uterus, about 20% of patients with complete lesions will develop into choriocarcinoma malignant tumors, and even metastasize to organs such as the liver, kidneys, lungs, brain, and vagina.